威而鋼無法預防高山病AMS
Wilderness medicine at high altitude: recent developments in the field Nitrates 體內一氧化氮 NO 生成, 可調節血管收縮狀態, 免疫功能, 血小板凝集, 血糖平衡, 肌肉收縮, 粒線體功能. 目前有證據顯示NO與高度適應有關, 在高度適應過程, NO 生成會增加, 低氧引起的適應反應在西藏人很明顯, 他們血清亞硝酸鹽濃度較高, 代表整體NO合成上升, 吐氣排出的NO也較多. Nitric oxide (NO) regulates physiological processes in the human body, including vasodilation, immune function, platelet aggregation, glucose homeostasis, muscle contraction, and mitochondrial function. Emerging evidence suggests that NO also plays an important role in altitude acclimatization. Lowlanders exposed to altitude initially exhibit reduced concentrations of exhaled NO, with the magnitude of this decline associated with susceptibility to altitude illness. With acclimatization, lowlanders demonstrate an increase in NO production. The adaptive response to hypoxia is particularly prominent in Tibetans who have greater plasma nitrite concentrations, indicative of elevated whole-body NO production, and higher exhaled NO relative...